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Depakote (valproic acid) is a prescription medication used to treat seizures and bipolar disorder, and to prevent migraines. Common side effects of Depakote include drowsiness, dizziness, nausea, vomiting, indigestion, diarrhea, weight loss, tremors, and skin reactions such as hair loss, rash, itching, and sensitivity to sunlight.
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… serum levels alone should not necessarily be taken at face value.
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Valproic acid-induced hyperammonemic encephalopathy may occur in people with normal liver function, despite normal doses and serum levels of VPA
In general, serum or plasma valproic acid concentrations are in a range of 20–100 mg/l during controlled therapy, but may reach 150–1500 mg/l following acute poisoning. Monitoring of the serum level is often accomplished using commercial immunoassay techniques, although some laboratories employ gas or liquid chromatography.
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Dosage. A physician will take frequent blood tests, probably twice weekly initially, to determine the therapeutic level.
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